Janumet 50mg/1000mg tablet is a combination medicine containing sitagliptin and metformin. It is used along with a healthy diet and regular exercise for the control of high blood sugar in patients having Type 2 diabetes mellitus. This medicine works by increasing insulin production and restoring the natural response of the body to insulin.

It should be taken as directed by the doctor and in doses and duration as prescribed. Nausea or vomiting, flatulence (gas), loose motion or constipation and stomach pain are some of the side effects of Janumet 50mg/1000mg tablet. Most of these are temporary but if you feel the side effects persist or your condition worsens, you should contact your doctor immediately.

Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding and about all the medicines and supplements you take and all the conditions or diseases you suffer from, before starting Janumet 50mg/1000mg tablet.

Medicinal Benefits

Janumet 50 mg 1000 mg helps the pancreas produce more insulin, effectively utilise insulin, and decrease the excess sugar the liver makes. It helps control the rise of blood sugar levels after a meal. Besides this, it does not cause weight gain in prolonged use. Janumet 50 mg/1000 mg Tablet plays a vital role in controlling blood sugar levels.

It prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

How Janumet Works

Sitagliptin works by inhibiting the DPP-4 enzyme, which results in increased levels of incretin hormones. These hormones help regulate blood sugar levels by increasing insulin production in response to meals and decreasing the amount of glucose produced by the liver. By enhancing the body's natural ability to control blood sugar levels, sitagliptin helps maintain a more stable and healthier glucose level.

Metformin, on the other hand, works by reducing the amount of glucose produced by the liver and improving the body's sensitivity to insulin. It decreases intestinal absorption of glucose and enhances peripheral glucose uptake and utilization. This helps to lower blood sugar levels and improve insulin sensitivity, making it easier for the body to utilize the insulin it produces.

How to take Janumet

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

  • Take one tablet:
    • twice daily by mouth
    • with meals to lower your chance of an upset stomach.
  • Your doctor may need to increase your dose to control your blood sugar.
  • If you have reduced kidney function, your doctor may prescribe a lower dose.

You should continue the diet recommended by your doctor during treatment with this medicine and take care that your carbohydrate intake is equally distributed over the day.

This medicine alone is unlikely to cause abnormally low blood sugar (hypoglycaemia). When this medicine is used with a sulphonylurea medicine or with insulin, low blood sugar can occur and your doctor may reduce the dose of your sulphonylurea or insulin.

Contraindications of Janumet 50mg/1000mg Strip Of 15 Tablets

  • If you are allergic to sitagliptin, metformin or any other ingredients of Janumet 50mg/1000mg tablet.
  • If your diabetes is not under control and you also have high blood sugar, nausea, vomiting, loose motions, rapid loss of weight, pain in the stomach, breathing difficulty, sleepiness etc.
  • If you have a recent history of a heart attack.
  • If you have severe kidney or liver disease.
  • If you are a lactating mother.
  • If you have to go to do an x-ray or scan and dye is injected in your blood before doing the x-ray or scan.
  • If you are a heavy alcohol drinker.
  • If you have dehydration or you have the presence of severe infection.